Characterization of highly pathogenic viruses obtained from field specimens
to elucidate the molecular mechanisms that control viral replication.
The mechanisms for pathogenicity of viruses is also evaluated using small animal models.
Live cell imaging systems based on infecting viruses and a non-infectious live cell imaging system based
on the ectopic proteins expression are constructed to elucidate
the intracellular dynamics of highly pathogenic viruses.
The ultrastructure of viral protein complexes is also analyzed using electron microscopy.
Spatio-temporal virus-host interactions are elucidated using
live cell imaging microscopy and electron microscopy.
Both Virus and host factors that regulate viral replication
and virulence are evaluated at the cellular and individual level,
contributing to the development of preventive and therapeutic agents.
